{"id":17877,"date":"2018-07-25T09:35:01","date_gmt":"2018-07-25T09:35:01","guid":{"rendered":"https:\/\/strammer.com\/?p=17877"},"modified":"2018-07-25T09:35:01","modified_gmt":"2018-07-25T09:35:01","slug":"stem-cells-help-repairing-brain-diseases","status":"publish","type":"post","link":"https:\/\/strammer.com\/es\/stem-cells-help-repairing-brain-diseases\/","title":{"rendered":"Stem Cells That Could Help Repairing Brain Diseases"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-fullwidth-1  fusion-parallax-none nonhundred-percent-fullwidth\" style=\"border-bottom-width: 0px;border-top-width: 0px;border-bottom-style: solid;border-top-style: solid;padding-bottom:20px;padding-top:20px;padding-left:;padding-right:;\"><style type=\"text\/css\" scoped=\"scoped\">.fusion-fullwidth-1 {\r\n                            padding-left: px !important;\r\n                            padding-right: px !important;\r\n                        }<\/style><div class=\"fusion-row\"><div class=\"fusion-title title fusion-title-center fusion-title-size-one\"><div class=\"title-sep-container title-sep-container-left\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#a36160;\"><\/div><\/div><h1 class=\"title-heading-center\"><span style=\"color: #a36160;\">Quiescent Stem Cells In Brain\u00a0Could\u00a0Repair Brain Diseases<\/span><\/h1><div class=\"title-sep-container title-sep-container-right\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#a36160;\"><\/div><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep sep-none\" style=\"margin-left: auto;margin-right: auto;margin-top:;\"><\/div><p style=\"text-align: justify;\">Scientists at the <strong>Wellcome Trust\/ Cancer Research UK Gurdon Institute, University of Cambridge,<\/strong> have identified a new type of stem cells in the brain which\u00a0might have a high <strong>potential<\/strong> for <strong>repairing<\/strong> following <strong>brain injury<\/strong> or disease.<\/p>\n<p style=\"text-align: justify;\">A major goal of regenerative research is to repair the brain efficiently following injury, for example due to <strong>stroke, Alzheimer\u2019s disease<\/strong> or <strong>head trauma<\/strong>, disease or<strong> ageing<\/strong>.<\/p>\n<p style=\"text-align: justify;\">The <strong>brain<\/strong> is known to be <strong>poor at repairing itself<\/strong>, however, it may become possible to improve this process without surgery. This could be realised by targeting stem cells\u00a0located in patients\u2019 brains. Stem cells have the unique capacity to produce all the cells in the brain.\u00a0Those cells are <strong>usually\u00a0kept inactive<\/strong> in a\u00a0way of &lsquo;cellular sleep&rsquo; known as a <strong>quiescence<\/strong>.<\/p>\n<p style=\"text-align: justify;\">Quiescent cells do not\u00a0vegetate or generate new cells. Thus, to target stem cells for any regenerative therapy\u00a0they must first be <strong>awoken<\/strong> from quiescence. In a published study about\u00a0<strong>PhD student Leo Otsuki<\/strong> and his supervisor <strong>Professor Andrea Brand<\/strong>, the discovery of a new quiescent stem cell residing in the brain has been reported, the <strong>G2 quiescent stem cell<\/strong>. The special characteristic about this stem cell is that it shows a <strong>higher regenerative potential<\/strong> than quiescent stem cells identified in the past. Moreover, the G2 quiescent stem cells are an <strong>attractive target for therapies<\/strong> where they can help <strong>regenerate brain diseases<\/strong> much faster than other quiescent cells.<\/p>\n<p style=\"text-align: justify;\"><em>\u201cThe brain is not good at repairing itself, but these newly-discovered stem cells suggest there may be a way to improve its ability\u201d<\/em>, says Professor Brand. <em>\u201cThese stem cells are in a dormant state, but once awake, they have the ability to <strong>generate key brain cells<\/strong>\u201d.<\/em><\/p>\n<p style=\"text-align: justify;\">By studying the fruit of fly, the authors identified a <strong>gene<\/strong> known as <strong>tribbles<\/strong> that selectively <strong>regulates<\/strong> G2 quiescent stem cells. The DNA of fruit flies has many similarities with that of humans, making them a useful model to understand human biology, and <strong>60% of human genes<\/strong> associated with disease are also <strong>found in Drosophila<\/strong>. The tribbles gene has counterparts in the mammalian genome that are expressed in stem cells in the brain.<\/p>\n<p style=\"text-align: justify;\">The researchers believe, drugs that target tribbles might be one form to help awaken\u00a0G2 quiescent stem cells. <strong>Student Leo Otsuki<\/strong> mentions, they have found a gene that directs these cells to become quiescent in the first place. This is a useful information for <strong>identifying potential drug-like molecules<\/strong>, that block this exact gene and <strong>awaken the stem cells<\/strong> as a consequence. <em>\u201cWe believe there may be similar quiescent stem cells in other organs, and this discovery could help improve or develop new regenerative medicines\u201d.<\/em><\/p>\n<p><span style=\"text-decoration: underline; color: #b2999d;\">References<\/span><\/p>\n<ul>\n<li>News Medical Life Science. Sally Robertson (April, 2018). Waking up stem cells in the brain could improve its ability to repair injury. Available at: <em>https:\/\/www.news-medical.net\/news\/20180406\/Waking-up-e2809csleepinge2809d-stem-cells-in-the-brain-could-improve-its-ability-to-repair-injury.aspx\u00a0<\/em><\/li>\n<li>Innovation Stem Cell Center. (April, 12th, 2018). Waking up sleeping stem cells may mean new treatments for Alzheimers. Available at: <em>http:\/\/www.innovationsstemcellcenter.com\/about-us\/blog\/waking-up-sleeping-stem-cells-may-mean-new-treatments-for-alzheimer-s-disease.html<\/em><\/li>\n<\/ul>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":17879,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","myguten_meta_block_field":"","footnotes":""},"categories":[98],"tags":[],"class_list":["post-17877","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts\/17877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/comments?post=17877"}],"version-history":[{"count":0,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts\/17877\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/media\/17879"}],"wp:attachment":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/media?parent=17877"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/categories?post=17877"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/tags?post=17877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}