{"id":18851,"date":"2018-12-11T10:52:41","date_gmt":"2018-12-11T10:52:41","guid":{"rendered":"https:\/\/strammer.com\/?p=18851"},"modified":"2018-12-11T10:52:41","modified_gmt":"2018-12-11T10:52:41","slug":"edible-bacteria-treating-phenylketonuria","status":"publish","type":"post","link":"https:\/\/strammer.com\/es\/edible-bacteria-treating-phenylketonuria\/","title":{"rendered":"Edible Bacteria To Treat a Rare Inherited Disease"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-fullwidth-1  fusion-parallax-none nonhundred-percent-fullwidth\" style=\"border-bottom-width: 0px;border-top-width: 0px;border-bottom-style: solid;border-top-style: solid;padding-bottom:20px;padding-top:20px;padding-left:;padding-right:;\"><style type=\"text\/css\" scoped=\"scoped\">.fusion-fullwidth-1 {\r\n                            padding-left: px !important;\r\n                            padding-right: px !important;\r\n                        }<\/style><div class=\"fusion-row\"><div class=\"fusion-title title fusion-title-center fusion-title-size-one\" style=\"margin-bottom:20px;\"><div class=\"title-sep-container title-sep-container-left\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#a36160;\"><\/div><\/div><h1 class=\"title-heading-center\"><span style=\"color: #a36160;\">Researchers Have Created Edible Bacteria to Treat Phenylketonuria<\/span><\/h1><div class=\"title-sep-container title-sep-container-right\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#a36160;\"><\/div><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep sep-none\" style=\"margin-left: auto;margin-right: auto;margin-top:;\"><\/div><p style=\"text-align: justify;\"><span style=\"color: #000000; background-color: #ffffff;\">Researchers from <\/span>Synologic have found a way to treat a <strong>rare inherited disease called phenylketonuria<\/strong> by creating a peppermint concoction filled with <strong>billions of bacteria<\/strong>. They did so by manipulating microbes to break down the naturally occurring toxins in the blood.<\/p>\n<p style=\"text-align: justify;\">Phenylketonuria (PKU) is a rare inherited disease where the body rejects a key constituent of an <strong>amino acid called phenylalanine<\/strong>. A build-up of phenylalanine in the blood could potentially <strong>damage neurons in the brain<\/strong> which could lead to psychiatric disorders, delayed development and intellectual disability.<\/p>\n<p style=\"text-align: justify;\">Patients with PKU have <strong>limited treatment options available<\/strong>. Traditionally, treatment for PKU is a low protein diet avoiding meat and cheese along with shakes filled with <strong>nutritional supplements<\/strong>.<\/p>\n<p style=\"text-align: justify;\">Synologic\u2019s president and chief executive officer, JC Guitierrez-Ramos said, \u201cIt is a serious disease that can be managed, but takes a toll on individuals and certainly, the more we interact with PKU patients and their families, the more we understand what they need. We think that this program could lead to a very important drug, and that\u2019s what we\u2019re working toward.\u201d<\/p>\n<p style=\"text-align: justify;\">Researchers were able to insert genes into the <strong>bacteria\u2019s DNA to break down phenylalanine<\/strong> the way our own cells do once they arrive in the gut. The phenylalanine is then sucked up by a pump that is encoded by new gene and broken into fragments. Once the bacteria encode new genes, it then gets released as urine.<\/p>\n<p style=\"text-align: justify;\">Today, <strong>drugs to drive down levels of phenylalanine are available<\/strong>. However, they come with their own side effects and only work with a fraction of patients.<\/p>\n<p style=\"text-align: justify;\">The executive director of the National PKU Alliance, Christine S. Brown says, \u201cthe current tools that we have available are not good enough\u201d.<\/p>\n<p style=\"text-align: justify;\">Research teams have wanted to use synthetic biology to form microbes that treat us from inside the body.<\/p>\n<p style=\"text-align: justify;\">This bacterial drink could become <strong>the first synthetic biology-based medical treatment<\/strong> to receive approval from the Food and Drug Administration. Before this, bacterial treatments have been industrial. This is<strong> promising in the scientific field<\/strong> known as scientific biology.<\/p>\n<div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep sep-none\" style=\"margin-left: auto;margin-right: auto;margin-top:;margin-bottom:10px;\"><\/div><p><span style=\"text-decoration: underline;\"><span style=\"font-size: 10pt;\">References<\/span><\/span><\/p>\n<ul>\n<li><span style=\"font-size: 10pt; color: #000000;\">The Scientist. (https:\/\/www.the-scientist.com\/news-opinion\/synthetic-bacteria-help-treat-phenylketonuria-in-mice-64656). August 17, 2018. Diana Kwon. Synthetic Bacteria help Treat Phenylketonuria in Mice.<\/span><\/li>\n<li><span style=\"font-size: 10pt; color: #000000;\">RareDR. (https:\/\/www.raredr.com\/news\/synb1618-pku-enters-the-clinic). April 19, 2019. Mathew Shanley. Can Probiotic Bacteria Treat PKU? Potential Therapy Enters the Clinic.<\/span><\/li>\n<li><span style=\"font-size: 10pt; color: #000000;\">World AIDS Day. (<a style=\"color: #000000;\" href=\"http:\/\/www.worldaidsday.org\/about\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.worldaidsday.org\/about\/<\/a>). About World AIDS Day\u00a0The New York Times. (https:\/\/www.nytimes.com\/2018\/09\/04\/health\/synthetic-biology-pku.html). September 4, 2018. Carl Zimmer. Scientists Are Retooling Bacteria to Cure Diseases.<\/span><\/li>\n<\/ul>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":18852,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","myguten_meta_block_field":"","footnotes":""},"categories":[98],"tags":[],"class_list":["post-18851","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts\/18851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/comments?post=18851"}],"version-history":[{"count":0,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts\/18851\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/media\/18852"}],"wp:attachment":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/media?parent=18851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/categories?post=18851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/tags?post=18851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}