{"id":19018,"date":"2018-12-27T10:53:41","date_gmt":"2018-12-27T10:53:41","guid":{"rendered":"https:\/\/strammer.com\/?p=19018"},"modified":"2018-12-27T10:53:41","modified_gmt":"2018-12-27T10:53:41","slug":"drug-delivery-across-blood-brain-barrier","status":"publish","type":"post","link":"https:\/\/strammer.com\/es\/drug-delivery-across-blood-brain-barrier\/","title":{"rendered":"Better Drug Delivery"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-fullwidth-1  fusion-parallax-none nonhundred-percent-fullwidth\" style=\"border-bottom-width: 0px;border-top-width: 0px;border-bottom-style: solid;border-top-style: solid;padding-bottom:20px;padding-top:20px;padding-left:;padding-right:;\"><style type=\"text\/css\" scoped=\"scoped\">.fusion-fullwidth-1 {\r\n                            padding-left: px !important;\r\n                            padding-right: px !important;\r\n                        }<\/style><div class=\"fusion-row\"><div class=\"fusion-title title fusion-title-center fusion-title-size-one\" style=\"margin-bottom:20px;\"><div class=\"title-sep-container title-sep-container-left\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#a36160;\"><\/div><\/div><h1 class=\"title-heading-center\"><span style=\"color: #a36160;\">Scientists Discover a Way To Get Drugs To The Brain More Efficiently <\/span><\/h1><div class=\"title-sep-container title-sep-container-right\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#a36160;\"><\/div><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep sep-none\" style=\"margin-left: auto;margin-right: auto;margin-top:;\"><\/div><p style=\"text-align: justify;\">Researchers from the University of Rochester Medical Center (URMC) have discovered a way to potentially <strong>deliver drugs to the brain more efficiently<\/strong>.<\/p>\n<p style=\"text-align: justify;\">Due to the difficulty of getting enough drugs into the brain effectively, many therapies for central nervous system diseases have failed in clinical trials. Indeed, the brain is protected by a <strong>complex system of molecular gateways<\/strong>, which control what can enter and exit the brain.<\/p>\n<p style=\"text-align: justify;\">The purpose of the blood-brain barrier is to<strong> protect the brain against pathogens and toxins<\/strong> that can cause brain infections. At the same time, it allows <strong>vital nutrients<\/strong> to enter to maintain levels of hormones, nutrients and water. Therefore, many mental and neurological disorders do not have the possibility to be treated with <strong>potential drug treatments<\/strong>: it is estimated that only 2% of therapies enter the organs.<\/p>\n<p style=\"text-align: justify;\">Research from 2015 showed that using an ultrasound to open the blood\u2013brain barrier can improve cognition and decrease the amount of toxic plaque that accumulates in the brain. A further study in 2017 demonstrated ultrasound as a promising tool to open the blood-brain barrier temporarily. They dispute that it can release more therapeutic antibodies to the brain which can improve pathologies of Alzheimer\u2019s and <strong>understanding antibody drugs in isolation<\/strong>.<\/p>\n<p style=\"text-align: justify;\">Co-Director of the Centre of Translational Neuromedicine at URMC, and lead author of the study <strong>Dr Maiken Nedergaard<\/strong> said, \u201cImproving the delivery of drugs to the central nervous system is a<strong> considerable clinical challenge<\/strong>. The findings of this study demonstrate that the brain\u2019s waste removal system could be harnessed to transport drugs<strong> quickly and efficiently into the brain<\/strong>.\u201d<\/p>\n<p style=\"text-align: justify;\">Nedergaard\u2019s and URMC\u2019s new research uses the power of the glymphatic system which was discovered in 2012. They were able to temporarily open the blood-brain barrier and inject mice with a hypertonic saline. This triggered an ion imbalance pulling cerebral spinal fluid out of the brain. They \u201ctricked\u201d the blood-brain barrier into allowing the passage of the administered antibodies directly into the cerebral spinal fluid, through the blood by a<strong> transporter protein<\/strong>.<\/p>\n<p style=\"text-align: justify;\">As this is happening the glymphatic system flows new cerebral fluid into the brain tissue along with the carried antibodies.<\/p>\n<p style=\"text-align: justify;\">Thanks to the discovery, the way <strong>Alzheimer\u2019s<\/strong>, <strong>Parkinson\u2019s<\/strong>, <strong>ALS<\/strong> and <strong>brain cancer<\/strong> are treated could have <strong>positive implications<\/strong>.<\/p>\n<div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep sep-none\" style=\"margin-left: auto;margin-right: auto;margin-top:;\"><\/div><p><span style=\"text-decoration: underline; font-size: 10pt;\">References<\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt; color: #000000;\">University of Rochester Medical Center. (<a style=\"color: #000000;\" href=\"https:\/\/www.urmc.rochester.edu\/news\/story\/5451\/study-points-to-new-method-to-deliver-drugs-to-the-brain.aspx\" target=\"_blank\" rel=\"noopener\">https:\/\/www.urmc.rochester.edu\/news\/story\/5451\/study-points-to-new-method-to-deliver-drugs-to-the-brain.aspx<\/a>). October 18, 2018. Study Points to New Method to Deliver Drugs to the Brain.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt; color: #000000;\">Forbes. (<a style=\"color: #000000;\" href=\"https:\/\/www.forbes.com\/sites\/robinseatonjefferson\/2018\/11\/18\/scientists-discover-a-way-to-get-drugs-to-the-brain-faster-and-more-efficiently\/#2bea2f95f95b\" target=\"_blank\" rel=\"noopener\">https:\/\/www.forbes.com\/sites\/robinseatonjefferson\/2018\/11\/18\/scientists-discover-a-way-to-get-drugs-to-the-brain-faster-and-more-efficiently\/#2bea2f95f95b<\/a>). November 18, 2018. Robin Seaton Jefferson. Scientists Discover A Way To Get Drugs To The Brain Faster And More Efficiently<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt; color: #000000;\">Drug Target Review. (<a style=\"color: #000000;\" href=\"https:\/\/www.drugtargetreview.com\/news\/36234\/deliver-blood-brain\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.drugtargetreview.com\/news\/36234\/deliver-blood-brain\/<\/a>). October 19, 2018. Iqra Farooq. Better drug delivery through the blood-brain barrier.<\/span><\/li>\n<\/ul>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":19019,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","myguten_meta_block_field":"","footnotes":""},"categories":[98],"tags":[],"class_list":["post-19018","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts\/19018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/comments?post=19018"}],"version-history":[{"count":0,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/posts\/19018\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/media\/19019"}],"wp:attachment":[{"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/media?parent=19018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/categories?post=19018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/strammer.com\/es\/wp-json\/wp\/v2\/tags?post=19018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}